Persistent serum immune complexes in syphilis.

Correspondence: An attempt to produce immune complexes in experimental syphilis.

Serum Reactions in Syphilis

now being paid to the development of precipitation methods for the serum diagnosis of syphilis, the present time is opportune for a consideration of the relative value of the more important of these tests and a comparison with those which depend upon complement fixation, i.e., the Wassermann test. It is a very remarkable fact that the test introduced eighteen years ago by Wassermann and his co-...

The Localization of Circulating Immune Complexes in Experimental Serum Sickness

In serum sickness, mechanisms by which circulating immune complexes become localized in the walls of vessels and glomeruli have been studied. In affected arteries, morphologic observations showed that circulating marker particles of carbon would rapidly deposit along the luminal surface of the internal elastic lamina. This, as in previous studies, suggested an increase in vascular permeability ...

Normal serum levels of immune complexes in postpolio patients

OBJECTIVE The pathophysiology of the postpolio syndrome is not fully understood. Increased cytokine levels in cerebrospinal fluid and peripheral blood indicate a systemic inflammatory process. Decreased cytokine levels and the clinical effect of intravenous immunoglobulin treatment further indicate an inflammatory/immunological pathogenesis. The aim of the present study was to evaluate whether ...

Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes.

As a prelude to characterization of the host and treponemal antigens present in purified immune complexes from the sera of rabbits with disseminated syphilis, autoradiographic and immunoenzymatic analyses of solubilized extracts of Treponema pallidum, Treponema phagedenis biotype Reiter, and Treponema refringens were performed on electroblots of polypeptides first separated by sodium dodecyl su...